Obesity and sex-specific central nervous system autoimmunity in females
Mechanisms by which obesity and female sex synergize to facilitate CNS autoimmunity remain elusive.
The researchers reveal a female-specific effect of obesity in triggering Th1 inflammatory signatures in humans and augmenting IFN-g/STAT1 signaling in mouse CD4+ T cells through type I IFN signaling, thereby exacerbating CNS autoimmunity.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00288-2
