How ketamine promotes behavioral perseverance
Ketamine can trigger lasting changes in behavior and mood.
The researchers show that astroglial calcium is recruited at active-to-passive transitions during learned-helplessness like assays in both zebrafish and mice and that a variety of antidepressant compounds have consistent effects across both species.
Ketamine, applied transiently, causes acute norepinephrine mediated astrocytic hyperactivation followed by prolonged suppression to promote lasting behavioral resilience.
