How transition from local to global Ca2+ signals regulated?
The researchers show that binding of PIP2 to IP3 receptors primes them to respond to IP3.
PIP2 depletion reduces the frequency of Ca2+ puffs and delays global Ca2+ signals.
Dynamic regulation of PIP2 levels by endogenous signaling pathways controls the transition from local to global Ca2+ signals.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00742-1
