Hydrogen sulfide generation extends lifespan and healthspan
Longevity-promoting interventions are known to enhance endogenous hydrogen sulfide generation, which plays key role in various biological functions, like, antioxidant defenses, mitochondrial bioenergetics, etc via cysteine persulfidation.
However, it is not known how enhanced hydrogen sulfide generation extends health span and lifespan in mammals.
The researchers demonstrate that hydrogen sulfide generators (Diallyl disulfide and diallyl trisulfide) found in garlic extend lifespan and enhance metabolic, neurocognitive, and locomotor function in male mice.
These molecules induce hepatic lipid-droplet remodeling and modulate aging associated pathways at transcriptomic, proteomic, and persulfidomic levels.
The researchers also show that in humans, greater protein persulfidation in individuals with polypathological conditions was associated with increased muscle strength and lower triglyceride levels, supporting its physiological relevance.
In humans, increased cysteine persulfidation correlates with relevant aspects of health.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00526-1
