Inflammasome post-translational modifications!
NLRP3 inflammasome priming is a tightly regulated process integrating transcriptional and posttranslational events.
Post-translational modifications control NLRP3 stability, localization, and partner interactions.
Recent advances reveal critical roles for palmitoylation in licensing NLRP3 for activation.
Interplay between modifications coordinates to prime NLRP3.
Understanding priming-specific regulation may enable selective inhibition of pathological NLRP3 activity while preserving protective immunity.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00252-2
