Lipids in Microglial Biology

Lipids act as immunomodulators in maintaining cellular health and function. 

Immune cells of the brin, microglia, regulate lipid metabolism both extracellularly and intracellularly through various signaling events.

Phagocytosis and migration are influenced by glycerophospholipids and fatty acids, that  interact with microglial cell surface protein receptors.  Ina addition, Moreover, lipid droplet the formation, function, and accumulation and  microglial survival is regulated by cholesterol and fatty acids. Also, acylcarnitines and ceramides, participate in various signaling pathways within microglia.

The authors in this review article, discuss, novel analytical techniques for characterizing the microglial lipidome and their roles in modulating microglial function.

https://onlinelibrary.wiley.com/doi/full/10.1002/glia.24654

https://sciencemission.com/Lipids:-Emerging-Players-of-Microglial-Biology