Low-intensity pulsed ultrasound modulates disease progression in ALS
Loss of motor neurons in the brain and spinal cord are characteristics of ALS without any treatment. The authors investigated the effect of low-intensity pulsed ultrasound (LIPUS) on motor cortex of SOD1G93A mouse model of ALS.
The researchers demonstrate that LIPUS on the motor cortex leads to delayed disease progression in a mouse model of ALS.
Enhanced cerebral blood flow, which is achieved by maintaining vascular endothelial cell integrity and increasing microvascular density, is crucial for the protective effects of LIPUS in ALS. LIPUS also substantially reduced the expression of genes associated with neuroinflammation.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01011-8
