Mapping the mind–mitochondria connection
Mitochondria transform the oxygen we breathe and the food we eat to power all brain–body or mind–body processes that produce human experiences.
Experimental studies in animals with mitochondrial defects show that mitochondria influence the perception of stressors and/or the resulting psychobiological responses relevant to resilience and aging.
Different individuals exhibit qualitative and quantitative differences in their affective, neural, and physiological stress responses; these may in part be explained by interindividual differences in mitochondrial biology, a question not previously examined in humans.
The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study includes participants with rare genetic mitochondrial lesions, plus psychobiological stressresponse paradigms to examine the mind–mitochondria connection with as much specificity as possible in humans.
The MiSBIE dataset and biobank include deep, multivariate phenotyping covering the hallmarks of psychobiology, detailed in the supplemental information online for this article, and data can be requested by the scientific community from the MiSBIE team.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(24)00225-X
