Mechanical signaling in neuronal migration
Neurons migrate via repeated leading process extension and somal translocation. This study shows that these two steps are linked by mechanical signaling, induced by plasma membrane tension and mediated by mechanosensitive ion channels, allowing rapid and saltatory neuronal migration.
The researchers show that leading process extension increases plasma membrane tension in migrating neurons. The increase in tension activates the mechanosensitive ion channel Tmem63b and triggers Ca2+ influx, which, induces actomyosin contraction and somal translocation.
Thus, the authors demonstrate that tension-mediated signaling is required for efficient and saltatory 3D neuronal migration.
https://www.embopress.org/doi/full/10.1038/s44318-024-00326-8
