Meningeal brain borders and migraine headache genesis

Persistent activation and increased mechanical responsiveness of nociceptive neurons that innervate the cranial meninges are considered to be the key processes underlying migraine pain genesis.

Meningeal neurogenic inflammation involving neuropeptide-driven neurovascular and neuroimmune interactions likely drives meningeal nociceptors in migraine.

Meningeal arteries may directly activate sensitized meningeal nociceptors during vasodilatation or indirectly via local elaboration of pro-nociceptive mediators.

In migraine with aura, nociceptive molecules generated in the cortex in response to cortical spreading depolarization (CSD) could activate and sensitize meningeal nociceptors directly or indirectly via an axon reflex and neurogenic inflammation.

Migraine treatments target sensory neuropeptides and receptors located in meningeal vascular, immune, neuronal, and glial cells.

https://www.cell.com/trends/neurosciences/abstract/S0166-2236(24)00155-3

https://sciencemission.com/Meningeal-brain-borders-and-migraine-headache-genesis