The cell biology of hippocampal neurons with dendritic axon origin
The axon emanates from a basal dendrite called axon-carrying–dendrite (AcD), is a privileged route for action potential generation at the axon initial segment (AIS). But it is not clear how such unusual morphology is established and whether the structure and function of the AIS in AcD neurons are preserved.
The researchers show that the development of AcD morphology can occur prior to synaptogenesis and independently of the in vivo environment using dissociated hippocampal cultures. A single precursor neurite first gives rise to the axon and then to the AcD.
The authors note that AcD contains lesser cisternal organelles, and receives fewer inhibitory inputs.
https://rupress.org/jcb/article/224/1/e202403141/277061/Unveiling-the-cell-biology-of-hippocampal-neurons
