Microglia transcriptional states and their functional significance
Based on challenging microenvironment, brain microglia continuously adapts to specific developmental or disease-related demands and develop diverse transcriptional states.
The authors in this review look at transcriptional diversity in microglia depending on the contexts and context-specific signatures under non-homeostatic conditions.
The researchers also evaluate the relationship between transcriptional states and microglial function that influence complex microenvironments and prior experiences on microglial state induction.
They also discuss strategies to bridge the gap between mouse and human studies to advance microglia-targeting therapeutics.
https://www.cell.com/immunity/fulltext/S1074-7613(25)00172-4
