Microglial reprogramming reduces brain metastases
The researchers reveal that microglial Rela/NF-kB activation promotes melanoma brain metastasis.
Targeting this pathway reprograms microglia, enhancing antitumor immunity, reducing metastases, and improving responses to immunotherapies.
This study highlights the therapeutic potential of targeting Rela/NF-kB in patients with melanoma brain metastases.
https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00026-1
https://sciencemission.com/Microglial-reprogramming-in-brain-metastases
