Developmental mitochondrial complex I activity determines lifespan

Many human diseases are  associated with aberrant mitochondrial function.

The authors show that developmental but not adulthood complex I (CI) depletion reduces lifespan, increases stress sensitivity and alters metabolic homeostasis despite comparable reduction in CI activity but, depletion of CI in adulthood only is not sufficient to reduce lifespan in Drosophila.

They also demonstrate that CI dysfunction in early development in Short-lived flies have tissue-specific transcriptomic alterations affecting the fat body, heart, and midgut and carry metabolic alterations likely related to atrophy of the adult fat body.

https://www.embopress.org/doi/full/10.1038/s44319-025-00416-6

https://sciencemission.com/Developmental-mitochondrial-complex-I-activity-determines-lifespan