Mitophagy routes governed by ubiquitylation and mitochondrial import
Structural and biochemical studies of PINK1 activation and stabilisation have captured TOM complex interactions and the formation of a PINK1–TOM– TIM supercomplex.
USP30 inhibition shows promising preclinical indications.
FBXL4 is a major suppressor of NIX/ BNIP3-dependent mitophagy.
PPTC7 scaffolds the interaction of FBXL4–SCF ligase with BNIP3 and NIX. Control of PPTC7 mitochondrial import sets the levels of BNIP3 and NIX.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00003-0
