Neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells

Modeling the neuromusculoskeletal (NMS) axis with organoids is challenging. 

The researchers developed hPSCs derived NNMS organoids (hNMSOs) with co-development, self-organization, and functional connection of neural, muscular, and skeletal tissues.

hNMSOs revealed skeletal impacts on muscular development and neuromuscular function.

These findings provide a model for studying human NMS crosstalk and disease.

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00404-1

https://sciencemission.com/neuromusculoskeletal-tri-tissue-organoids