Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids
Identifying biomarkers of neurodegenerative diseases (NDs) in easily accessible fluids is crucial for advancing monitoring and treatment.
It is emerging that brain-derived extracellular vesicles (BDEVs) can transport toxic misfolded proteins, potentially promoting the spread of protein aggregates and ND progression.
BDEVs can cross the blood–brain barrier, reaching peripheral body fluids.
The physicochemical properties and molecular composition of BDEVs reflect the condition of their originating cells, providing insights into cellular health and disease states.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(25)00046-X
https://sciencemission.com/Monitoring-neurodegeneration-through-BDEV-in-biofluids
