Mouse γδ T cells in cancer immunity
Mouse γδ T cells are not all the same; rather, they comprise seven subsets that influence progression in several cancer types.
Antitumor γδ T cell subsets can be tissue-resident or circulating cells, which generally rely on glycolysis for energy production, and they mediate cancer cell death via interferon-gamma or orchestration of antitumor immunity.
Protumor γδ T cell subsets use lipids for energy production, and they promote primary tumor growth and metastasis through the production of interleukin17A to modulate the behavior of myeloid cells.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(26)00040-2
