Mps1 kinase functions in mitotic spindle assembly and error correction
Mps1 promotes mitotic checkpoint complex assembly and the establishment of bioriented chromosome attachment to spindle microtubules.
Mps1 is a multidomain protein kinase that harbors protein motifs mediating its function in the SAC. These motifs are highly conserved during evolution, but with some important deviations that are species specific.
The molecular description of Mps1 roles in SAC signaling and error correction has enhanced our understanding of the mechanisms that govern cell division.
Defects in cell division result in gross chromosome segregation errors and genome instability. Inhibition of Mps1 catalytic activity to interfere with mitosis progression in tumor cells is a promising therapeutic window for the treatment of aggressive types of cancer.
Mps1 may also be a suitable target for the treatment of infections caused by diverse pathogens, such as fungi.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00032-5
