NAD+/NADH ratio linked to bacterial infection mediated alterations in innate immunity
The researchers find that bacterial infection alters macrophage metabolism and changes the NAD+ /NADH ratio.
Modulation of NADH production shifts the NAD+ /NADH ratio, which impacts proinflammatory responses and type I IFN responses divergently, highlighting that the NAD+ /NADH ratio is an essential cell-intrinsic factor that orchestrates antimicrobial innate immunity.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00999-9
