Neuron–tumor communication in solid tumors

Neuron–tumor communication exists along a spectrum, ranging from bona fide synapses to pseudo-synaptic interfaces. 

Pseudo-synapses may fulfill canonical synaptic ultrastructure while exhibiting noncanonical signaling outputs.

Peripheral tumors may exploit localized neurotransmitter signaling without fully mature synaptic architecture.

 Defining neural dependencies may enable neuro-targeted cancer therapies.

https://www.cell.com/trends/cancer/fulltext/S2405-8033(26)00136-6

https://sciencemission.com/Neuron%E2%80%93tumor-communication