Repeated fasting alters gene expression programs!

Frequent and prolonged fasting is a recurrent daily energy stress that benefits health-span and lifespan. 

While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood.

The authors show that mice undergoing alternate-day fasting (ADF) respond profoundly differently to a following fasting bout compared to mice first experiencing fasting.

They demonstrate that many genes enabling ketogenesis were induced during fasting and revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer binding in liver was also enhanced.as a keystone for ketone production.

https://academic.oup.com/nar/article/53/1/gkae1161/7915244

https://sciencemission.com/Repeated-fasting-events-sensitize-enhancers