Novel antagonists reveal the mechanism of PXR inhibition

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Novel antagonists reveal the mechanism of PXR inhibition

The pregnane X receptor (PXR) is a key regulator of metabolism, but the mechanisms underlying its antagonism remain unclear. 

Researchers reported potent new antagonists and their co-crystal structures, revealing molecular determinants of PXR antagonism and paving the way for developing antagonists as therapeutics and preventing undesirable PXR activation.

https://www.nature.com/articles/s41467-024-48472-1

https://sciencemission.ayurmatrika.com/Chemical-manipulation-of-an-activation-inhibition-switch-in-the-nuclear-receptor-PXR