Optic nerve regeneration therapeutics

The optic nerve is an accessible and anatomically simple system to study factors that inhibit or promote axon regeneration. 

Using optic nerve crush and other injury models, numerous classic retinal ganglion cell-intrinsic factors and cellextrinsic environments have been identified in the regulation of regenerative growth.

Evolving therapeutic strategies promote long-distance regeneration, focusing on proper axon guidance and reinnervation of central targets to restore visual function.

High-throughput sequencing and multiomics technologies have expanded molecular target identifications for optic nerve regeneration, offering a more comprehensive understanding of the regeneration process.

Gene-based therapies, pharmacological treatments, and noninvasive light stimulation have offered clinical translation opportunities, although significant challenges remain.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(24)00249-9

https://sciencemission.com/Emerging-therapeutic-strategies-for-optic-nerve-regeneration