Common pathways in primary age-related tauopathy and Alzheimer’s disease
Tau pathology is similar in primary age-related tauopathy (PART) and Alzheimer’s disease (AD) but is distinct in other tau pathologies.
The researchers identify shared transcriptional signatures and synaptic gene changes associated with tau pathology in primary age-related tauopathy and Alzheimer’s disease.
They show that the genes in the up-regulated signature were enriched in calcium regulation and synaptic function. In addition, transcriptional changes associated with intraneuronal tau in PART and AD were similar, suggesting a possible mechanistic relationship.
This study highlights the power of molecular analysis stratified by pathology and provides insight into common pathways associated with tau pathology in aging and Alzheimer’s.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00193-7
