Protein quality control machinery
Recruitment of protein quality control (PQC) machinery to biomolecular condensates is an additional spatiotemporal regulatory mechanism for PQC in cells.
The multivalency and oligomerization stemming from the architecture and interactions among ubiquitin(Ub)-binding adaptor proteins, polyUb chains, chaperone proteins, and proteasomes make these PQC components ideal candidates to be recruited into condensates or to form their own.
Substrate ubiquitination drives the assembly of condensates that are precursors for immune system activation, autophagosome formation, DNA repair, and endocytosis.
Dysregulation of condensates is one hypothesized mechanism leading to the formation of protein-containing inclusions found in neurodegenerative disorders.
https://www.sciencedirect.com/science/article/pii/S0968000424002755
