Phase separation in autophagy
Phase separation plays a central role in organizing autophagy across all stages of the pathway from cargo recognition to autophagosome formation.
The coordinated action of phase separation, avidity, and wetting enables the selective condensation, recognition, and engulfment of diverse autophagy substrates.
Deciphering these physical principles at the molecular level opens new avenues to therapeutically target disease-associated cargoes through the autophagy pathway.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00244-0
