Plasma biomarkers for brain aging!
The researchers used proteomics to identify brain aging biomarkers. Using brain imaging data from 10,949 healthy adults and proteome-wide association analysis across 4,696 participants they identified 13 proteins significantly linked to brain aging.
Brevican (BCAN) and growth differentiation factor 15 showed the most significant, and multiple, associations with dementia, stroke and movement functions. Dysregulation of BCAN affected multiple cortical and subcortical structures.
The authors also found changes in the concentrations of affected blood proteins peak at 57, 70, and 78 years old.
