Plasticity of RNA-binding proteins in cancer
Extensive research has shown that RNA-binding proteins (RBPs) can influence all cancer hallmarks via post-transcriptional regulation of gene expression.
Many RBPs are considered to be prognostic markers in cancer, and are emerging as important targets for therapeutic intervention through the development of drugs targeting RBPs.
Multiple RBPs play contrasting roles across cancer contexts and can facilitate or suppress cancer depending on the type, subtype, or stage of cancer.
The ability of an RBP to bind to a substrate, and the consequences of binding, are highly dependent on cell type-specific modifications of RBPs, their substrates, and interacting regulatory proteins and RNAs.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00253-5
