Reinitiation-stimulating element (RSE) RNAs identified!
Certain viruses with bicistronic mRNAs use reinitiation to translate the downstream open reading frame.
The researchers use bioinformatics to find new examples of RNA structures that mediate reinitiation, verify their function, and determine the structure of a viral reinitiation-stimulating RNA bound to the ribosome.
They show that the viral RNA structure can sample a range of conformations while remaining tethered to the ribosome, enabling the ribosome to find a reinitiation start site within a limited range of mRNA sequence.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00007-5
https://sciencemission.com/translation-reinitiation-in-viruses
