Regulating extracellular vesicle biogenesis and secretion from activated microglia
Inflammatory signals and aggregated proteins are spread from the activated microglia through secretion of extracellular vesicles (EVs) .
The researchers show that Selenoprotein P (Sepp1) is a key regulator of ATP-induced secretion of EVs by microglia.
Sepp1-deficient microglia show impairment in expression of genes associated with EV biogenesis machinery and display increased lysosomal activity. Silencing of Sepp1 in astrocytes but not neurons suppresses EV secretion in vitro.
Downregulation of Sepp1 halts hypersecretion of EVs by amyloid plaque-associated microglia.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01376-7
