Pancreatic cancer without KRAS mutation

The researchers identify that loss of p53/ SMAD4 or p53/TGFBR2 can induce spontaneous pancreatic tumor development in the absence of KRAS mutation in mice.

Pancreatic tumors harboring p53/SMAD4 loss exhibit an adenosquamous phenotype with a distinct microenvironment landscape, while pancreatic tumors harboring p53/ TGFBR2 loss exhibit an adenocarcinoma phenotype.