Reprogramming chaperones into epichaperomes by post-translational modifications
Post-translational modifications (PTMs) can convert molecular chaperones into epichaperomes – stable scaffolds that restructure protein–protein interaction (PPI) networks in disease.
PTMs on chaperone intrinsically disordered regions act as molecular switches, reprogramming their conformation and interactions to drive network-level dysfunction.
Epichaperomes enable large-scale PPI rewiring without altering protein levels or sequence, emerging in cell states like pluripotency and disease.
Epichaperomes are stable, ordered assemblies that scaffold high-demand pathways central to disease, including mitosis, metabolism, and synaptic signaling.
This reframes disease as a disorder of PPI networks and supports a network centric strategy for therapeutic intervention.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00169-0
