Restoring mitochondrial calcium uptake declines during aging
The researchers identify that aging and disability impair mitochondrial calcium uptake in skeletal muscle via mitochondrial calcium uniporter regulator1 (MCUR1).
Food-derived polyphenols increase the import of calcium in mitochondria by binding mitochondrial calcium uptake 1 (MICU1).
The natural MCU activator oleuropein stimulates energy metabolism, ameliorates muscle performance, and reverses age-related muscle decline by increasing mitochondrial calcium.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00417-0
