Role for hypoxia-inducible factor signaling during human craniotomy infection
The cellular and molecular signatures associated with craniotomy (a neurosurgical procedure) infection in human subjects are unknown.
The researchers characterize immune attributes of 2,500 human craniotomy infections where >45% of cases were attributed to S. aureus.
Transcriptional profiling revealed leukocyte diversity typified by a prominent G-MDSC signature and altered immunometabolic profiles, including hypoxia-inducible factor 1a (HIF1a).
The importance of HIF signaling was validated using a mouse model of Staphylococcus aureus craniotomy infection, where HIF inhibition increases chemokine production and leukocyte recruitment, exacerbating tissue pathology.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00537-8
