Role of neutrophils in glioma progression
Life expectency for glioma is less than 2 years as there is limited therapeutic options available to treat the disease. Also the immunosuppressive mechanisms governing the disease remain incompletely understood.
The researchers report the identification and characterization of immunosuppressive neutrophils within human and mouse glioma tumors.
The presence of such disease-specific suppressive granulocytes (DSSGs) correlates with glioma grades and poor clinical outcomes.
Blockage of DSSGs, which partly originate from the skull bone marrow and meninges, strongly delays tumor progression.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01365-2
