Schizophrenia-risk gene haploinsufficiency leads to cognitive and behavioral impairments
Recent studies have shown that protein-truncating variants of exportin 7 (XPO7) can increase the risk of schizophrenia.
The researchers generated mice with Xpo7 haploinsufficiency and showed the impairments in cognitive and social behavior in the mice.
They also demonstrate a total of 45 molecules including CutC, Rbfox3, and Gria3 interact with Xpo7 and are affected by Xpo7 haploinsufficiency.
The authors used single-nucleus RNA sequencing analysis and revealed an overlap between the molecules affected by Xpo7 haploinsufficiency and the high-risk genes associated with schizophrenia and identify 15 gene expression changes in the frontal cortex correlating with the progressive stages of Xpo7 haploinsufficiency in mice.
https://www.embopress.org/doi/full/10.1038/s44319-024-00362-9
