Signaling dynamics in developing neural tube
The researchers develop an in vitro stencil-based system for 2D ESC differentiation system that produces self-organized patterns of cell types similar to the ones observed in the dorsal neural tube.
They find that to form these patterns, cells respond to sequential phases of BMP signaling, and they show how these phases are regulated.
The authors show that Lmx1a links subnetworks of BMP signaling that operate at different timescales.
https://www.cell.com/developmental-cell/fulltext/S1534-5807(24)00664-6
