Targeting EGFR deficiency-associated inflammation and scarring alopecia
Chronic microbial folliculitis associated with EGFR deficiency initiates hallmarks of scarring alopecia.
The authors show that defective EGFR signaling induces hypersensitive JAK-STAT1 pathway leading to hair follicle destruction.
They also demonstrate that CD8 T-cells and NK-cells expressing IFNγ trigger the JAK-STAT1 cascade.
Therapeutic JAK1/2 inhibition alleviates skin inflammation, restores barrier integrity and leads to hair regrowth.
https://www.embopress.org/doi/full/10.1038/s44321-024-00166-3
