Stem-like CD4 T cell differentiation for immune modulation
CD4 T cell differentiation is crucial for balancing effective immune defense and disease pathology.
Stem-like CD4 T cells are present among antigen-specific CD4 T cells. This unique population retains self renewal and differentiation capacity, and helps to sustain effector responses that mediate disease outcomes across chronic conditions.
Stem-like CD4 T cells may also exhibit multipotency to differentiate into various helper subsets, and thus provide a potential explanation for CD4 T cell plasticity.
Targeting stem-like CD4 T cell differentiation could represent a novel therapeutic strategy for immune modulation across various diseases.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00129-1
