Strategies to boost antibody selectivity in oncology

Antibody therapeutics in oncology can have high cytotoxic potential, which demands superior on-tumor selectivity. 

Antibody selectivity can be boosted through molecular engineering strategies that exploit the unique characteristics of the tumor and the tumor microenvironment.

Strategies, such as super selectivity, dual targeting, conditional binding, inverse targeting, and combinations of molecules, can help boost the selectivity of biologics for tumor cells.

Intracellular tumor antigens are becoming increasingly accessible to biologics through approaches including T cell receptor mimicry, intracellular delivery, and transcytosis.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(24)00217-7

https://sciencemission.com/Strategies-to-boost-antibody-selectivity-in-oncology