Mitochondria and lysosomes in T cell immunometabolism
Organelles, especially mitochondria and lysosomes, are crucial hubs orchestrating the metabolic fate and functional adaptation of T cells in response to different inflammatory insults or tissue microenvironments.
Beyond their bioenergetic and degradative functions, mitochondria and lysosomes coordinate extracellular and intracellular signaling cues to orchestrate T cell-mediated adaptive immunity.
Mitochondria and lysosomes regulate cell fate decisions via organelle crosstalk, and dysregulation of either mitochondrial or lysosomal fitness is frequently associated with dysfunction in the other organelle.
Aberrant mitochondrial or lysosomal function contributes to immunemediated diseases and is a potential target for therapeutic intervention.
https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00181-4
