TYK2 regulates tau phosphorylation and aggregation in a tauopathy mouse model

Tau’s microtubule-stabilizing function is regulated by its phosphorylation.

However, hyperphosphorylation of tau may lead to tauopathies such as Alzheimer’s disease (AD).

The researchers demonstrate that tyrosine kinase 2 (TYK2) phosphorylates tau at tyrosine 29, promoting its stabilization and aggregation by interfering with autophagic clearance.

They show that TYK2-mediated phosphorylation of Tyr29 facilitates pathological tau accumulation in tau-transgenic mice and knockdown of Tyk2 reduced total tau and pathogenic tau levels and rescued gliosis in a tauopathy mouse model. 

https://www.nature.com/articles/s41593-024-01777-2

https://sciencemission.com/TYK2-regulates-tau-phosphorylation