The mitochondrial long non-coding RNA suppresses Alzheimer’s disease
lncMtDloop was recently identified as a noncoding RNA expressed in the brain and encoded in the mitochondria.
The researchers show that lncMtDloop interaction with mitochondrial transcription factor TFAM.
lncMtDloop expression is lower in brains of human AD patients and in AD mouse model brains.
Fusing a mitochondrial targeting sequence to the terminal end of lncMtDloop for gain-of-function studies results in lncMtDloop restoration in mitochondria of AD mouse-model brains.
Expressing lncMtDloop in AD mouse models causes amelioration of AD-like pathology, of mitochondrial function and morphological abnormalities, and of behavioral deficits.
https://www.embopress.org/doi/full/10.1038/s44318-024-00270-7
