Epigenetic regulation of hematopoietic stem cell fate

The epigenetic landscape differs between individual hematopoietic stem cells (HSCs) with distinct lineage bias.

Epigenetically encoded HSC lineage bias is detectable prior to initiation of lineage specific gene expression.

Inflammation and infection induce trained immunity in HSCs via epigenetic memory.

Age-associated functional decline and skewed lineage output is linked to disruption of the epigenetic landscape in HSCs.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00162-4

https://sciencemission.ayurmatrika.com/Epigenetic-regulation-of-hematopoietic-stem-cell-fate