The molecular architecture of the nuclear basket

Nucleocytoplasmic transport is mediated by the nuclear pore complex (NPC). Although NPC role in mRNA surveillance and chromatin organization is well studied, an architectural understanding has remained elusive.

The elusive architecture of the nuclear basket reveals that a double ring is necessary to stabilize a hub of nucleoporins (Nups) from which the struts emanate.

The basket’s distal density contains the N/C termini of the strut-forming proteins that serve as a docking platform for cargo and nuclear periphery elements.

https://www.cell.com/cell/fulltext/S0092-8674(24)00780-3

https://sciencemission.com/The-molecular-architecture-of-the-nuclear-basket