The role of chromodomain protein CDYL in human cortical development
The human embryonic cortex expresses the transcriptional corepressor chromodomain Y-like (CDYL) in diverse cell populations, but, its precise role in cortical development remains unclear.
The researchers reveal that CDYL is essential for human cortical neurogenesis, with its deficiency causing an increase in GABAergic neurons in cortical organoids.
CDYL regulates neuronatin (NNAT), influencing the fate commitment of cortical neural stem cells, highlighting CDYL’s critical role in neural stem cell fate commitment and human cortex development.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01165-3
