Transient promoter interactions modulate developmental gene activation

Changes in chromatin topologies during transcriptional induction involves increase in promoter-enhancer interactions. However, coordinated of topological changes across time and space during transcriptional activation is not clearly not known.

The researchers show that genome folding dynamics and the magnitude of transcriptional induction are linked during ESC differentiation. The researchers detect transiently formed interactions and demonstrate by genetic deletions that associated distal regulatory elements (DREs), as well as appropriate formation and disruption of these interactions, can contribute to the transcriptional induction of linked genes.

Thus, pervasive transient interactions can contribute to full activation of connected genes, irrespective of their chromatin signature. This activity can involve temporal facilitation of promoter interactions with strong enhancers.

https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00828-1

https://sciencemission.com/Transient-promoter-interactions-modulate-developmental-gene-activation