The inositol phosphate signalling network in physiology and disease
InsPs and inositol pyrophosphates (PPInsPs) are responsive to receptor activation cascades and metabolic processes.
InsPs and PP-InsPs act on proteins through multiple mechanisms, ranging from transient binding to serving as a structural cofactor, while PP-InsPs additionally transfer their high-energy β-phosphate to proteins.
The development of mouse knockout models has emphasised the importance of InsP/PP-InsP kinases in the control of fundamental physiological processes and pathophysiological states.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(24)00192-0
