Role of microtubules in human handedness
Human handedness is a moderately heritable trait.
Large-scale genome-wide association and exome sequencing studies have identified multiple genes associated with handedness and highlighted a role of tubulin genes.
Axon guidance, axon growth, and forming the inner structure of motile cilia are key processes regulated by tubulin genes that may also be relevant for handedness,
Tubulin genes are associated with several psychiatric disorders which may offer insights into biological pathways mediating the link between handedness, brain asymmetries, and psychiatric disorders.
https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00006-X
